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Wednesday, January 27, 2021

Missing ingredient to treat schizophrenia

New research has uncovered that a subgroup of people with schizophrenia may benefit from vitamin A treatment, found in foods such as salmon, cheddar cheese and liver.

The investigation was led by professor Murray Cairns, from the University of Newcastle and Hunter Medical Research Institute (HMRI).

“We investigated common genetic variation associated with schizophrenia and observed changes in 22 genes involved with the metabolism and function of vitamin A, which is part of the retinoid system,” professor Cairns said.

“Vitamin A is responsible for good health and is essential for neural development, connectivity and plasticity.

“Our findings suggest that up to a third of people with schizophrenia have an above-average risk for retinoid system dysfunction.
“By identifying people at excess risk with a simple and cheap saliva test, we could immediately begin to improve their symptoms by treating them in a more targeted way through dietary interventions and clinically available pharmaceuticals that regulate the system.”

While previous evidence supports the link between retinoids and schizophrenia, these findings claim to be the first to identify a genetic burden in the retinoid signalling pathway that changes their function in people with the disorder.

Professor Cairns said, while it was not entirely clear what initiated schizophrenia, 80% of the risk appeared to be inherited, with the remainder caused by environmental factors such as infection in utero and psychosocial reasons, including neglect and traumatic experiences.

Psychosis, withdrawal, memory problems and a loss of motivation are just some of the symptoms of the complex mental health disorder that about 1% of Australians are likely to develop throughout their lifetime.

“The condition and its genetic determinants also varies from one person to another, but there are three main groups of symptoms – positive, negative and cognitive,” professor Cairns said.
“A substantial proportion of the people diagnosed with schizophrenia have a severe cognitive deficit that impacts their memory and ability to work and relate to people.
“With no cure available and most people living with the disorder throughout their life, these findings reveal promising potential for the use of precision medication to help better manage the symptoms of schizophrenia.”

The study used data from 500 participants involved with the Australian Schizophrenia Research Bank, with clinical trials a necessary next step to measure and compare the effect of vitamin A dietary and related pharmaceutical interventions.

The research was carried out in partnership with the University of New South Wales, Neuroscience Research Australia and Monash University.

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