A 42-year-old male driver has been charged with high-range drink driving after crashing his grey SUV at North Arm Cove overnight.

The man, who allegedly blew 0.157 during a secondary breath test, was travelling north on the Pacific Highway at about 10:30pm when his vehicle veered into oncoming traffic before colliding with a van and coming to rest in a nearby nature strip.

The 51-year-old male driver of the van, and his 55-year-old female passenger were treated at the scene by paramedics before the female was taken to John Hunter Hospital for further assessment.

The driver of the SUV was assessed at the scene by NSW Ambulance paramedics before officers from Port Stephens-Hunter Police District conducted a roadside breath test which returned a positive result.

He was arrested and taken to Raymond Terrace Police Station where he underwent a secondary breath analysis.

He is due to appear at Raymond Terrace Local Court next month.

The female passenger in the van has been released from hospital.

Inquiries into the circumstances surrounding the crash are continuing.